The present invention relates to a combination of compounds for introducingnucleic acids and/or protein into animal cells, tissue, organs or organisms invitro, extracorporal, or in vivo. This combination comprises preparationssuitable for administration to an animal or human for medical purposes,comprising as one component a bacterial vector genetically manipulated tocontain nucleic acid sequences comprising a transgene, and a second componentfor the subsequent transcription, possibly translation of the transgene bycontrolled induction of bacterial vector as it is present within the animal orhuman.