Hille, Thomas,Wauer, Gabriel,Smith, Kevin John,Mundin, Gillian Elizabeth,Johnson, Helen Elizabeth
申请号：
AU2012327247
公开号：
AU2012327247B2
申请日:
2012.12.12
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2012327247B220151224.pdf#####- 189ABSTRACT The invention relates to transdermal therapeutic system for the transdermal 5 administration of buprenorphine, comprising a buprenorphine-containing selfadhesive layer structure comprising A) a buprenorphine-impermeable backing layer, and B) a buprenorphine-containing pressure-sensitive adhesive layer on said buprenorphine-impermeable backing layer, the adhesive layer comprising 10 a) at least one polymer-based pressure-sensitive adhesive, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof, and c) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid and linolenic acid, levulinic acid and mixtures thereof, in 15 an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein to form a mixture. and the carboxylic acid buprenorphine mixture forms dispersed deposits in the said pressure-sensitive adhesive, wherein said buprenorphine-containing pressure-sensitive adhesive layer is the skin 20 contact layer.
