Preparation of controlled release sterile injectable Aripiprazole which, after the Injection, releases AripiprazoleA formulation of controlled release sterile Aripiprazole dried by freezing, and a method for its preparation
VIJAY H. NARINGREKAR,MANOJ NERURKAR,TAKAKUNI MATSUDA,JANUSZ W. KOSTANSKI
申请号：
ARP160103230
公开号：
AR106449A2
申请日:
2016.10.21
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
An injectable formulation of controlled release sterile aripiprazole, which, after the Injection, releases AripiprazoleComprising: (a) aripipriopazol with a particle size of 1 to 10 mm, (b) a vehicle for this, and (c) Water for injectionsWhere the formulation is in the form of a sterile suspension homogeneous.A controlled release formulation of sterile Aripiprazole dried by freezing, and a method for its preparation.Claim 1: an injectable formulation of controlled release sterile aripiprazole, which, after the Injection, releases AripiprazoleCharacterized in that it comprises: (a) aripipriopazol with a particle size of 1 to 10 mm, (b) a vehicle for this, and (c) Water for injectionsWhere the formulation is in the form of a sterile suspension homogeneous.Claim 22: a method to prepare Freeze Dried sterile formulation according to claim 16Characterized in that it comprises the steps of: (a) preparing sterile Aripiprazole in volume, which has a desired particle size Distribution.(b) Prepare a sterile vehicle for Aripiprazole in volume (c) combine this sterile, sterile and sterile Aripiprazole the vehicle to form a primary suspension, sterile(d) reduce the average particle size of the primary suspension sterile Aripiprazole in within the range of 1 to 10 mm to form a sterile suspension end(e) by freezing and drying to form the final suspension sterile formulation by freeze drying.Una formulación inyectable estéril de aripiprazol, de liberación controlada la cual, después de la inyección, libera aripiprazol, que comprende: (a) aripipriopazol con un tamaño de partícula medio de 1 a 10 mm, (b) un vehículo para este, y (c) agua para inyección, en donde la formulación está en la forma de una suspensión estéril homogénea. Una formulación de aripiprazol estéril de liberación controlada secada por congelamiento, y un método para su preparación. Reivindicación 1: Una formulación inyectable estéril de aripiprazol, de liberación controlada la cual, después de la inyección, libera a
