GRIMM JAN,WEIHOFEN ANDREAS,HOCK CHRISTOPH,NITSCH ROGER,SU LIHE,WEINREB PAUL
申请号：
NZ61891412
公开号：
NZ618914A
申请日:
2012.06.22
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is an isolated antibody or antigen-binding fragment thereof that specifically binds to human &alpha-synuclein (SEQ ID NO: 1), said antibody or antigen-binding fragment comprising: -a VH CDR1 region comprising the amino acid sequence of NYAMH or a sequence that differs from NYAMH by one amino acid -a VH CDR2 region comprising the amino acid sequence of WINAGNGKRKYSQKFQD or a sequence that differs from WINAGNGKRKYSQKFQD by one amino acid -a VH CDR3 region comprising the amino acid sequence of EEDHAGSGSYLSMDV or a sequence that differs from EEDHAGSGSYLSMDV by one amino acid -a VL CDR1 region comprising the amino acid sequence of KSSQNVLYSSNNKNYLA or a sequence that differs from KSSQNVLYSSNNKNYLA by one amino acid -a VL CDR2 region comprising the amino acid sequence of WASTRES or a sequence that differs from WASTRES by one amino acid and -a VL CDR3 region comprising the amino acid sequence of QQYYSSPLT or a sequence that differs from QQYYSSPLT by one amino acid.
