PROBLEM TO BE SOLVED: To provide a method for producing a strongly metastatic human cancer cell line from a non-metastatic or weakly metastatic human cancer cell line, and to provide a strongly metastatic human cancer cell line obtained by the method.SOLUTION: The invention provides a strongly metastatic human cancer cell line obtained by co-implantation of non-metastatic or weakly metastatic human cancer cells and carcinoma-associated fibroblasts into an immunodeficiency nonhuman animal to proliferate in the body of the immunodeficiency nonhuman animal concerned.COPYRIGHT: (C)2015,JPO&INPIT【課題】非転移性又は弱転移性のヒト癌細胞株から強転移性ヒト癌細胞株を作製する方法及びその方法により得られる強転移性ヒト癌細胞株を提供することにある。【解決手段】非転移性又は弱転移性のヒト癌細胞と癌内線維芽細胞とを免疫不全非ヒト動物に共移植し、当該免疫不全非ヒト動物体内で増殖させることにより得られる強転移性ヒト癌細胞株。【選択図】なし
