HU SHAW,FEN SYLVIA - KANNAN GUNASEKARAN,LI YANG,STEVENS JENNITTE,KING CHADWICK TERENCE,YIE JUNMING,FOLTZ IAN
申请号：
ARP120102005
公开号：
AR086693A1
申请日:
2012.06.06
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Compositions and methods relating to or derived from Antigen binding proteins capable of Inducing B - Klotho, FGF21 mediated signaling and or type. In certain embodiments, the Antigen binding proteins that Bind specifically to a complex comprising B - Klotho and at least one fgfr1c (i), (ii) and (iii) fgfr2c fgfr3c.In some embodiments, the Antigen binding proteins induce type FGF21 Signaling.In some embodiments, a Protein Antigen binding Fragment of an Antibody, Union or derived from the Humanized or fully Human Antibody, Chimeric, and polypeptides that Bind specifically to a complex comprising B - Klotho and at least one fgfr1c (i), (ii) FGF Fgfr3c R2c and (iii).Other embodiments disclosed Nucleic Acids which encode these Proteins, Antigen binding, and fragments and Derivatives of the same, and polypeptides, cells comprising these polynucleotides, Methods to produce these proteins and Antigen binding Fragments, and deriv Two of the same, and polypeptides, and Methods for using such Antigen binding proteins.Fragments and Derivatives thereof, and polypeptides, including methods for the Treatment or diagnosis of subjects suffering from Type 2 diabetes, obesity, metabolic syndrome, Nash and Related Disorders or conditions.Composiciones y métodos que se refieren a/o derivan a partir de proteínas de unión al antígeno capaces de inducir a b-Klotho, y o la señalización mediada tipo FGF21. En ciertas realizaciones, las proteínas de unión al antígeno se unen específicamente a un complejo que comprende b-Klotho y al menos uno de (i) FGFR1c, (ii) FGFR2c y (iii) FGFR3c. En algunas realizaciones, las proteínas de unión al antígeno inducen la señalización tipo FGF21. En algunas realizaciones, una proteína de unión al antígeno es un anticuerpo, fragmento de unión o derivado de dicho anticuerpo completamente humano, humanizado o quimérico, y polipéptidos que se unen específicamente a un complejo que comprende b-Klotho y al menos uno de (i) FGFR1c, (ii) FGFR2c y (iii) FGFR3c. Otras
