PROBLEM TO BE SOLVED: To provide compositions for inhibiting androgen dependent or independent prostate cancer cells which are used for prostate cancer, inhibit activation of androgen receptors, are effective for inhibiting the proliferation of androgen dependent or independent prostate cancer, inhibit the action even if AR-V7 has expressed, and are effective also to anticancer drug resistant cell lines and to provide pharmaceutical formulations of prostate cancer using the same.SOLUTION: A composition for inhibiting androgen dependent or independent prostate cancer cells comprises an α,β-saturated or unsaturated ketone derivative represented by the following chemical formula (1) or a pharmaceutically acceptable salt thereof. (X- represents a hydrocarbon aromatic ring group or an aromatic heterocyclic group, both or either of Y1- and Y2- are a hydrocarbon aromatic ring group or an aromatic heterocyclic group and the other is a hydrogen atom, Z= represents an atom or a functional group which forms or generates a ketone group, a thioketone group, an imino group, or an oxime group together with a bonding carbon atom, Y3- is a hydrogen atom, a perhalogeno hydrocarbon group or the like.) The pharmaceutical formulation of prostate cancer contains this composition.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】前立腺癌のために用いられ、アンドロゲン受容体の活性化を抑制し、アンドロゲン依存的又は非依存的な前立腺癌増殖の抑制に有効で、AR-V7が発現していてもその作用を抑制し、抗癌剤耐性の細胞株に対しても有効なアンドロゲン依存性又は非依存性前立腺癌細胞の抑制用の組成物、及びそれを用いた前立腺癌の医薬製剤を提供する。【解決手段】アンドロゲン依存性又は非依存性前立腺癌細胞の抑制用の組成物は、化学式(1)【化1】(X-は炭化水素芳香環基又は芳香族複素環基、Y1-及びY2-は両方又は一方が炭化水素芳香環基又は芳香族複素環基で他方が水素原子、Z=は結合炭素原子と共にケトン基、チオケトン基、イミノ基、又はオキシム基を成し又は生成する原子若しくは官能基、Y3-は水素原子、パーハロゲノ炭化水素基等)で表わされるα,β-飽和又は不飽和のケトン誘導体又はその薬学的に許容される塩を含む。前立腺癌の医薬製剤は、この組成物を含有する。【選択図】なし
