A new and distinct Pyrus communis L. pear tree variety named ‘PE2UNIBO’ is particularly characterized by the following features: medium vigorous trees with semi-upright growing habitus bearing habitus normally on spurs on 2-3 years old branches and on 1 year shoots good grafting compatibility with the main quince rootstocks early ripening (about 15 days before ‘Bartlett’) high and constant yield and early bearing good size of the fruit (over 200 g) with regular pyriform shape green skin at picking time and yellow-green at full ripening stage (after the cold storage), with an attractive red-orange over-color in the fruit surface previously exposed to sun tender, juicy and white flash, with a very good flavor (good sugar-acid balance) at full ripening stage long storage capacity in cold room, up to 5-6 months.