ABBATE, Antonio,ZHANG, Shizun,VAN TASSELL, Benjamin
申请号：
AU2015258273
公开号：
AU2015258273A1
申请日:
2015.11.20
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2015258273A120151210.pdf#####ABSTRACT CRYOPYRIN INHIBITORS FOR PREVENTING AND TREATING INFLAMMATION Inhibitors that are anti-inflammatory agents are provided, as are methods of using the analogs to inhibit inflammation and prevent or treat diseases and conditions associated with inflammation, such as heart failure and autoimmune diseases. 483/18 Scheme 1a COI, HO 0 H3CO + a b HN 0 HN 0 Cl NH2 H3CO H3CO 456 Cl 1 Cl 4d H2N H0 HN 0 HN 0 H3CO N H3CO 2 CI 3Cl aReaction agents and conditions: a) Et3N, 1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide, Dichloromethane (DCM)； b) CISO 3H, 85"C； c) NH3； d) H20, 100'C. Figure 3
