A blood purification apparatus includes a blood purifier (110), a vascular access flow path (120), a cleaning solution flow path (130), and a drainage flow path (150). The blood purifier (110) has an inner portion divided by a semi-permeable membrane (111) into a first portion (10) and a second portion (11). The vascular access flow path (120) is connected to the blood purifier (110) and is in communication with the first portion (10). The cleaning solution flow path (130) is connected to the blood purifier (110) and is in communication with the first portion (10). The drainage flow path (150) is connected to the blood purifier (110) and is in communication with the second portion (11). The cleaning solution flow path (130) is provided with a blood pump (170) capable of bidirectionally feeding a fluid. An open-close valve (180, 190) is provided in each of the vascular access flow path (120) and the drainage flow path (150).
