A method of manufacturing a collimator (134) on a three-dimensional printer (510) includes obtaining design specifications (536) for the collimator, the design specifications including a channel perimeter pattern and an overall collimator thickness, determining a first quantity of deposit layer permutation types based on the channel perimeter pattern, determining a respective second quantity of permutation layer elements (310, 320, 330) for each respective one of the deposit layer permutations, generating respective sets of sequences for each respective one of the deposit layer permutations, the number of sets equal to the respective second quantity for the corresponding deposit layer permutations, assembling the respective sets of sequences into a three-dimensional print file (538), providing the three-dimensional file to the three-dimensional printer, and manufacturing the collimator by depositing additive layers of material based on contents of the three-dimensional file. A system for implementing the method and a non-transitory computer-readable medium are also disclosed.
