AMY RIPKA,KEVIN SPROTT,JASON J. MARINEAU,DARBY SCHMIDT,MICHAEL BRADLEY,STEPHANE CIBLAT,M.,ARSHAD SIDDIQUI,ANZHELIKA KABRO,MELISSA LEBLANC,SERGE LEGER,STEPHANIE ROY,DANA K. WINTER,TOM MILLER,DANSU LI
申请号：
PT15721378
公开号：
PT3126352T
申请日:
2015.04.03
申请国别(地区):
PT
年份:
2018
代理人:
摘要：
The present invention provides novel compounds of Formulaand Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (cancers (leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.
