PROBLEM TO BE SOLVED: To provide a method and a composition for enhanced anti-tumor effector functioning of CD4+ and CD8+ T cells for cancer immunotherapy； and provide, in particular, an extracellular domain.SOLUTION: The present invention provides a tumor-specific chimeric antigen receptor which comprises a specific recognition element, an optional support or linker region, a transmembrane region, the signaling domain of CD3 zeta chain and the signalling domain of at least one additional costimulatory signaling receptor.SELECTED DRAWING: None【課題】癌免疫療法のためのCD4＋およびCD8＋T細胞の抗腫瘍エフェクター機能増進のための方法、及び組成物；そして特に細胞外ドメインの提供。【解決手段】特異的認識要素、場合による支持またはリンカー領域、膜貫通領域、CD3ゼータ鎖のシグナル伝達ドメイン、及び少なくとも1つのさらなる共刺激シグナル伝達受容体のシグナル伝達ドメインを含む、前記腫瘍特異的キメラ抗原受容体。【選択図】なし
