The present invention relates to compositions of Sonic Hedgehog (Shh) pathway activators and Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.本發明關於包含音蝟(Shh)途徑活化劑與Wnt促效劑之組成物及使用彼等組成物來誘導毛囊幹細胞自我更新的方法,包括誘導毛囊幹細胞增生同時於子細胞中維持分化成毛囊上皮細胞之能力。