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ANTIMYCOTIC PHARMACEUTICAL COMPOSITION
专利权人:
发明人:
KOBAYASHI HIROKAZU,KOSUGI EIKO,KUBOTA NOBUO
申请号:
IN8103/CHENP/2011
公开号:
IN285139B
申请日:
2011.11.04
申请国别(地区):
IN
年份:
2017
代理人:
摘要:
In a pharmaceutical composition for external use containing a compound such as luliconazole and/or a salt thereof in an amount of 5% by mass or more, comprised is/are acetone, a polyoxyethylene alkyl (having 8 to 30 carbon atoms) ether, and/or a polyoxyethylene alkenyl (having 8 to 30 carbon atoms) ether. Provided is a preparation using a solvent other than crotamiton, propylene carbonate, and N-methyl-2-pyrrolidone as a solvent for solubilization and steric stabilization and having the following properties: 1) when a compound represented by the general formula (1) and/or a salt thereof has a stereoisomer, the amount of the stereoisomer of the compound and/or a salt thereof produced under a preservation condition of 60°C for 3 weeks is 1% by mass or less with respect to the total mass of the compound and/or a salt thereof at the beginning of preservation; 2) the preparation is in a clear liquid state when preserved at a constant temperature of 20°C immediately after manufacture; and 3) no crystal is deposited when the preparation is preserved at 5°C for 2 weeks after manufacture.
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