The present invention provides a Ganoderma culture medium containing wheat germ. After fermented by Ganoderma, the Ganoderma culture medium turns into substance with active ingredients which could inhibit angiotensin converting enzyme activity. Thus, this Ganoderma culture medium could be used to prepare antihypertensive health drinks or antihypertensive pharmaceutical composition.本發明提供一種添加小麥胚芽的靈芝培養基。所述靈芝培養基經靈芝發酵後,靈芝培養基中產生血管收縮素轉化醇抑制活性成分,可用以製備抗高血壓之保健飲品或醫藥組成物。