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Pyridin- 2 - YL sulfanyl acid esters and process for the preparation thereof
专利权人:
Council of Scientific & Industrial Research
发明人:
Sarma, Jadab Chandra,Bora, Dilip Chandra,Rao, Paruchuri Gangadhar,Ghosh, Balaram,Balwani, Sakshi
申请号:
AU2011281132
公开号:
AU2011281132A1
申请日:
2011.07.20
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
The present invention relates to Pyridin-2-yl sulfanyl acid ester compounds having antiinflammatory properties. The present invention particularly relates to novel anti-inflammatory heterocyclic acid esters of Pyridin-2-yl sulfanyl having the structure of general formula 1 which have been screened for their antiinflammatory activity with respect to inhibition of adhesion of neutrophils, isolated from human peripheral blood, onto the surface of human umbilical vein endothelial cells (HUVEC) as a result of inhibition of the cytokine-stimulated expression of cell adhesion molecule ICAM-1. The compound RS-Z, 3-(Pyridin-2-yl sulfanyl)-propionic acid pentyl ester (structure la, R
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