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Pharmaceutical compositions
专利权人:
NOVARTIS AG
发明人:
LI, PING,CAO, YU,ZHU, JIAHAO,LI, SHOUFENG,HACKL, WOLFGANG,MIRZA, TAHSEEN,ZEHENDER, HARTMUT
申请号:
ECSP13012654
公开号:
ECSP13012654A
申请日:
2013.06.03
申请国别(地区):
EC
年份:
2013
代理人:
摘要:
The present Invention relates to a Pharmaceutical composition for oral administration of a Therapeutic Compound of the formula (i), which comprises Granules which comprise at least a Therapeutic Compound of the formula (i) (see below), in particular the 2 - methyl - 2 - [4 - (3 - methyl - 2 - oxo - 8 - quinolin-1 - 3 - il - 2,3 Dihydro imidazo [4,5 - C] quinolin-1 - 1 - il) phenyl] - propionitrilo (6 or 8 - methoxy - pyridin-3-yl) - 3 - methyl - 1 - [4 - (piperazin-1-yl - 3 - trifluoro methyl phenyl) - 1,3 Dihydro imidazo [4,5 - - C] quinolin-2 - one of, or a taut u00f3mero thereof, or a pharmaceutically acceptable Salt, or hydrate or solvate thereof; at least one you Nsoactivo nonionic Vitamin E TPGS - that is,In an amount in the range from about 15 to about 80 percent by weight of the composition; and at least one Agent Dissolution Enhancer selected from polyethylene glycol, poly ethylene oxide, and any combination of the above.The present Invention also relates to processes for the preparation of such Pharmaceutical compositions, and to a kit comprising the pharmaceutical Composition and the instructions provide that the pharmaceutical composition can be taken immediately to approximately Thirty Ta minutes after consumption of food; and to the Uses and Methods of treatment related.La presente invención se refiere a una composición farmacéutica para la administración oral de un compuesto terapéutico de la fórmula (I), la cual comprende gránulos que comprenden por lo menos compuesto terapéutico de la fórmula (I) (véase más adelante), en particular el 2-metil-2-[4-(3-metil-2-oxo-8- quinolin-3-il-2,3-dihidro-imidazo-[4,5-c]-quinolin-1-il)-fenil]-propionitrilo o la 8-(6-metoxi-piridin-3-il)-3-metil-1-(4-piperazin-1-il-3-trifluoro-metil-fenil)-1,3-dihidro-imidazo-[4,5-c]-quinolin-2-ona, o un tautómero de los mismos, o una sal farmacéuticamente aceptable, o un hidrato o un solvato de los mismos; por lo menos un tensoactivo no iónico que es la Vitamina E-TPGS, en una can
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