#$%^&*AU2012201546A120120405.pdf#####P:\OPER\DND\3O252491 div spci pages 177.doc.7/3/2O7 ABSTRACT Disclosed are therapeutic agents and methods to modulate the activity of an isoform ofversican V3, a splice variant of versican which is the major chondroitin sulphate 5 proteoglycan (CSPG) of the blood vessel wall.