연세대학교 산학협력단;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY;박민성;KIM, Yun Hee;INDUSTRY-ACADEMIC COOPERATION FOUNDATION;이진우;LEE, Jin Woo; YONSEI UNIVERSITY;PARK, Min Sung;김윤희
发明人:
LEE, Jin Woo,이진우,PARK, Min Sung,박민성,KIM, Yun Hee,김윤희
申请号：
KRKR2011/003732
公开号：
WO2012/121451A1
申请日:
2011.05.20
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
The present invention provides a method for inducing in vivo migration of a stem cell to a damaged joint region, the method comprising the steps of: (a) submerging a biodegradable scaffold in a solution having chemotactic factors； and (b) implanting the biodegradable scaffold to the damaged joint region. In addition, the present invention provides a method for treating a damaged joint including the step of implanting a biodegradable scaffold having interleukin (IL)-8, Macrophage Inflammatory Protein (MIP)-3α, or derivatives thereof to a damaged joint cartilage, and provides an implantable composition for treating a damaged joint cartilage having the biodegradable scaffold including IL-8, MIP-3α, or derivatives thereof as an active ingredient. The present invention enables treatment of a damaged joint cartilage by implanting the biodegradable scaffold reacted with the chemotactic factors (for example, IL-8 or MIP-3α) to the damaged area (for example, joint cartilage), and inducing/promoting homing of a stem cell (desirably, a mesenchyme stem cell). Thus, the biodegradable scaffold of the present invention are applied to the treatment of a damaged joint cartilage more conveniently and effectively compared to the conventional technology.La présente invention concerne une méthode d'induction de la migration in vivo d'une cellule souche vers la région d'une articulation endommagée, la méthode comprenant les étapes suivantes : (a) immersion d'un échafaudage biodégradable dans une solution comportant des facteurs chimiotactiques ； et (b) implantation de l'échafaudage biodégradable dans la région de l'articulation endommagée. De plus, la présente invention concerne une méthode de traitement d'une articulation endommagée, ladite méthode incluant l'étape d'implantation d'un échafaudage biodégradable comportant l'interleukine (IL)-8, la protéine MIP-3α (Macrophage Inflammatory Protein), ou leurs dérivés au niveau du cartilage d'une articulation endommagée, ainsi qu'une composi
