A pharmaceutical composition composed of a dietary fiber composition composed of from about 48% to about 90% (w/w) glucomannan, from about 5% to about 20% (w/w) xanthan gum, and from about 5% to about 30% (w/w) alginate in combination with at least one of metformin or sitagliptin or a combination thereof is described. The pharmaceutical composition is effective to lower elevated blood glucose levels and total blood cholesterol levels in a subject significantly more than the dietary fiber composition alone or a composition consisting of at least one of metformin or sitagliptin or a combination thereof.L'invention concerne des compositions de fibres alimentaires composées de 48-90% en poids de glucomannane, 5-20% en poids de gomme xanthane et de 5-30% en poids d'alginate en combinaison avec de la metformine, de la sitagliptine ou un mélange de celles-ci pour le traitement d'une maladie métabolique.
