YANG, Yan,MANDIYAN, Sreekala,ROBINSON, Brett,KIMMEL, Lida,HADARI, Yaron,JONES, Timothy, David,CARR, Francis, Joseph,HOLGATE, Robert George, Edward,WELDON, Richard
申请号：
EP16765587
公开号：
EP3270918A4
申请日:
2016.03.15
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Provided herein are compositions, methods and uses involving antibodies that specifically bind to MET, a receptor tyrosine kinase, and modulate the expression and/or activity of MET. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer. In one aspect, provided herein is a monoclonal antibody or antigen-binding fragment thereof that binds to the Sema/PSI domain of human MET. Also provided herein is a kit comprising an antibody or antigen-binding fragment provided herein. Also provided herein is a method of managing, protecting against, or treating cancer in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment provided herein.
