INFLUENZA VACCINES INCLUDING COMBINATIONS OF PARTICULATE ADJUVANTS AND IMMUNOPOTENTIATORS

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专利权人:

发明人:

Rino RAPPUOLI,Derek OHAGAN,Giuseppe DEL GIUDICE

申请号：

US14194525

公开号：

US20140248312A1

申请日:

2014.02.28

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen (ii) an insoluble particulate adjuvant and (iii) a immunopotentiator.

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