David A. Wink,Martin Feelisch,Pasquale Pagliaro,David A. Kass,Nazareno Paolocci,Katrina M. Miranda,Jon M. Fukuto
申请号：
US12346694
公开号：
US08268890B2
申请日:
2008.12.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Nitroxyl donating compounds are administered prior to the onset of ischemia for the prevention and/or reduction of ischemia/reperfusion injury in subjects at risk for ischemia. Nitroxyl donors also are administered to organs to be transplanted for the prevention and/or reduction of ischemia/reperfusion injury upon reperfusion in a recipient. Nitroxyl donors include any nitroxyl donating compound. In particular cases the nitroxyl donor is a nitroxyl-donating diazeniumdiolate, such as Angelis salt or IPA/NO.
