NOVEL PROCESS FOR PREPARATION OF FLUPIRTINE MALEATE

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专利权人:

发明人:

ANSARI SHAHID AKHTAR,HIRPARA HITIN MAGANBHAI,PANDYA DIVYANG JAGDISHCHANDRA,YADAV ASHOK KESHAVLAL,PATEL PRAVIN SHAMJIBHAI

申请号：

IN157/KOL/2010

公开号：

IN2010KO00157A

申请日:

2010.02.19

申请国别(地区):

IN

年份:

2012

代理人:

摘要：

(a) reduction of 2-amino-3-nitro-6-[(4-flurobenzyl)amino] pyridine (5) using Raney Ni and hydrazine hydrate to give 2,3-diamino-6-[(4-flurobenzyl)amino] pyridine (6), (b) ethoxycarbonylation of compound (6) to obtain flupirtine base (1) or its acid addition salt, and (c) treatment of flupirtine base (1) or its acid addition salt with maleic acid. The present invention further provides different methods to obtain crystalline Form A of flupirtine maleate.

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