AHMED, MAHMOOD,MYATT, JAMES,NORTON, DAVID,RIVERS, DEAN, ANDREW
申请号：
NZ57738707
公开号：
NZ577387A
申请日:
2007.12.19
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed are indole-indolizine derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof. Examples of such compounds include ethyl 3-[4-(5-{ 5-chloro-6-[(1-methylethyl)oxy]-3-pyridinyl} -1,2,4-oxadiazol-3-yl)-1H-indole-1-yl]propanoate. Also disclosed is the use of the compounds for treating diseases mediated by S1P1 receptors such as multiple sclerosis, autoimmune diseases, chronic inflammatory disorders, asthma, inflammatory neuropathies, arthritis, transplantation, Crohns disease, ulcerative colitis, lupus erythematosis, psoriasis, ischemia-reperfusion injury, solid tumours, and tumour metastasis, diseases associated with angiogenesis, vascular diseases, pain conditions, acute viral diseases, inflammatory bowel conditions, insulin and noninsulin dependent diabetes.
