In certain embodiments, the present invention relates to compounds, compositions, and methods for disrupting biofilms. In some embodiments, the compounds and compositions comprise unsaturated long chain alcohols and/or aldehydes, or combinations of such compounds. In further embodiments, the present invention contains therapeutic actives to help reduce and/or eradicate the bacteria in the biofilm once the film is disrupted.在某些實施例中,本發明涉及用於崩裂生物膜之化合物、組成物與方法。在某些實施例中,該化合物與組成物包含不飽和長鏈醇與/或醛,或此類化合物之組合。在進一步之實施例中,本發明含有治療活性物,一旦生物膜崩裂時,有助於減少與/或消滅生物膜中的細菌。