Use of an antibody, which specifically binds to the chemokine receptor (CCR) 2, for the production of a medicament for the treatment of multiple sclerosis and/or rheumatoid arthritis in the subject or which depletes the monocytes, for the production of a medicament for the treatment of multiple sclerosis or rheumatoid arthritis in a subject, is claimed. An independent claim is included for depletion of monocytes comprising contacting the monocytes with an antibody and excluding procedure that represents a surgical or therapeutic treatment of the human or animal body. ACTIVITY : Neuroprotective; Antiarthritic; Antirheumatic. MECHANISM OF ACTION : CCR2 binder.