Zhou, Tong,Kimberly, Robert P,Koopman, William J,Lobuglio, Albert F,Buchsbaum, Donald J
申请号：
NO20042269
公开号：
NO338458B1
申请日:
2004.06.01
申请国别(地区):
NO
年份:
2016
代理人:
摘要：
The present invention relates to a purified antibody which selectively binds a TRAIL receptor DR4 and shows no binding above 1.5 times background for DR5, DcR1 or DcR2, wherein said antibody, in its soluble form, has in vivo and in vitro apoptosis-inducing activity in target cells expressing DR4, wherein the apoptosis-inducing activity in vitro is characterized by less than 50% target cell viability at antibody concentrations of less than 0.1 µg/ml for use in the treatment of a disease.
