The bracket of offer has in each structural domain (such as CH2 and CH3) asymmetric heavy chain, come realize surmount with native homologous dimer (symmetrical) Fc molecules participation mediating effect+6 function various Fc receptors between selectivity, and obtain variant Fc homodimers increased stability and purity. These recruits are worked with what change antibody comprising design and find the compound of the heterogeneous component of natural way of purposes in therapeutic agent with it.提供的支架具有在各個結構域（例如CH2和CH3）不對稱的重鏈，來實現超越用天然同源二聚體（對稱）Fc分子的參與調節效應功能的各種Fc受體之間的選擇性，和獲得的變體Fc同源二聚體的增加的穩定性和純度。這些新分子包含設計用於改變抗體起作用和其在治療劑中找到用途的天然方式的異質組分的複合物。
