Lewis T. Williams,Elizabeth Bosch,Stephen K. Doberstein,Kevin Hestir,Diane Hollenbaugh,Ernestine Lee,Minmin Qin,Ali Sadra,Justin Wong,Ge Wu,Hongbing Zhang
申请号：
US13905042
公开号：
US09173957B2
申请日:
2013.05.29
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion molecules can be made in CHO cells and may comprise deletion mutations in the extracellular domains of the FGFRs which improve their stability. These fusion proteins inhibit the growth and viability of cancer cells in vitro and in vivo. The combination of the relatively high affinity of these receptors for their ligand FGFs and the demonstrated ability of these decoy receptors to inhibit tumor growth is an indication of the clinical value of the compositions and methods provided herein.
