An intelligent intervention method based on an integrated tire pressure monitoring system includes monitoring a tire pressure and a tire temperature of a vehicle, and monitoring, a wheel speed of the vehicle; transmitting the tire pressure, the tire temperature and the wheel speed to a host; judging in real time whether the vehicle is in a normal status or in an abnormal status, via integrating the tire pressure, the tire temperature and the wheel speed; producing a deviation signal, when the tire pressure, the tire temperature and the wheel speed deviate from normal thresholds and transmitting the deviation signal to an intelligent intervention system; and performing intelligent intervention to slow down the vehicle in a straight line until the vehicle stops, when the deviation signal is received. The method enables the vehicle to run safely until stopping even in case of tire blowout, so as to prevent rollover or collision.