This creation discloses a blood separation device, including: a body, including a body, an accommodation space provided inside the body to accommodate external blood to be separated, and a first opening opened in the body One end communicates with the accommodation space, and a second opening is opened at the other end of the body and communicates with the accommodation space； a cover portion is removably mounted on the first opening； a piston is connected to the accommodation space； Slidingly disposed in the accommodating space and abutting on the body with a peripheral end surface, and interposed between the first opening and the second opening.本創作係揭露一種血液分離裝置，包括：一本體，包括一身部，一設於該身部內部之容置空間，用以容納外部之待分離的血液，一第一開口，開設於該身部之一端，連通該容置空間，一第二開口，開設於該身部之另端，連通該容置空間；一蓋部，係可卸載地蓋設於該第一開口上；一活塞，係滑設於該容置空間中並以周側端面緊抵於該身部上，且介於該第一開口與該第二開口間。
