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NICOTINE FORMULATION
专利权人:
NICOCCINO AB
发明人:
HÜBINETTE FREDRIK
申请号:
IN8879DEN2014
公开号:
IN8879DEN2014A
申请日:
2014.10.22
申请国别(地区):
IN
年份:
2015
代理人:
摘要:
A method of manufacturing a nicotine containing mucoadhesive film by preparing an aqueous solution at a pH of from 9.5 to 13 said solution comprising (i) a nicotine salt (ii) an alkaline pH regulating agent and (iii) a film forming agent comprising an alginate salt of monovalent cation or a mixture of alginate salts of monovalent cations the film forming agent having a mean guluronate (G) content of from 50 to 85% by weight a mean mannuronate (M) content of from 15 to 50% by weight a mean molecular weight of from 30 000 g/mol to 90 000 g/mol and being such that a 10% aqueous solution thereof at a temperature of 20°C has a viscosity of 100 1000 mPas as measured at a shear rate of 20 rpm by use of a Brookfield viscometer with a spindle No. 2; distributing the solution onto a solid surface; and permitting the solution to dry on said surface. A nicotine containing mucoadhesive film.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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