Yunlong Song,Xiaodan Fu,Yunpeng Qi,Yves G. Pommier
申请号:
US13698739
公开号:
US09181193B2
申请日:
2011.05.17
申请国别(地区):
US
年份:
2015
代理人:
摘要:
An indenoquinolone compounds of Formula (A) is disclosed, wherein the definition of each group is described in the description. These compounds may specifically inhibit topoisomerase I, and they have good activities against many kinds of human tumor cells, such as lung cancer, colon cancer, breast cancer, liver cancer and the like. They can be used in the manufacture of antitumor drugs. The method for preparing the compound of formula (A), and pharmaceutical compositions containing such compounds and the use in the manufacture of antitumor drugs are also disclosed.