An object of the present invention is to provide a complete human anti-human TfR antibody that specifically recognizes human TfR, inhibits the survival and proliferation of cancer cells that highly express TfR, and is not immunogenic to humans. That is. According to the present invention, SEQ ID NOs: 1 to 1 as heavy chain first complementarity determining region (VH CDR1), heavy chain second complementarity determining region (VH CDR2), and heavy chain third complementarity determining region (VH CDR3), respectively. 3, 7-9, 13-15, 19-21, 25-27, 31-33, 37-39, 43-45, 49-51, 55-57, 61-63, 67-69, 73-75, An antibody that specifically reacts with human TfR, comprising any one of the amino acid sequences of 79-81, 85-87, 91-93, 97-99, 103-105, 109-111, 115-117, is provided.本発明の目的は、ヒトＴｆＲを特異的に認識し、ＴｆＲ高発現しているがん細胞の生存や増殖を阻害する、かつヒトに対し免疫原性ない完全なヒト抗ヒトＴｆＲ抗体を提供することである。本発明によれば、重鎖第１相補性決定領域（ＶＨ ＣＤＲ１）、重鎖第２相補性決定領域（ＶＨ ＣＤＲ２）、重鎖第３相補性決定領域（ＶＨ ＣＤＲ３）としてそれぞれ配列番号１～３、７～９、１３～１５、１９～２１、２５～２７、３１～３３、３７～３９、４３～４５、４９～５１、５５～５７、６１～６３、６７～６９、７３～７５、７９～８１、８５～８７、９１～９３、９７～９９、１０３～１０５、１０９～１１１、１１５～１１７の何れかのアミノ酸配列を含む、ヒトＴｆＲと特異的に反応する抗体が提供される。
