PROBLEM TO BE SOLVED: To provide a method of treatment of malignant glioma, particularly glioblastoma multiforme, which is a rare cancer and currently not treated with a satisfactory method so that prognosis is poor.SOLUTION: A pharmaceutical composition for treatment of malignant glioma contains 0.01 to 10 mg of macitentan per kg of patient body weight combined with a dose of 1 to 20 mg of temozolomide per kg of patient body weight per day, or a dose of 0.1 to 10 mg of paclitaxel per kg of patient body weight per day.【課題】まれな癌であり、現在のところ、満足できる治療方法がなく、また予後が不良な、悪性神経膠腫、特に多形膠芽腫の治療方法の提供。【解決手段】１日あたり、患者の体重１ｋｇあたり、１～２０ｍｇの用量のテモゾロミド、又は、１日あたり、患者の体重１ｋｇあたり、０．１～１０ｍｇの用量のパクリタキセルと、患者の体重１ｋｇあたり、０．０１～１０ｍｇのマシテンタンを組み合わせた、悪性神経膠腫の治療用の医薬組成物。【選択図】なし
