ABCD (amplaya, banaba, camote,duhat) is a pioneering herbal drug that combines the four widely used herbals for diabtes. Biologically active constituents found in these plants that have clinically demonstrated hypoglycemic properties, or other actions of potential benefit against diabetes mellitus are summarized and tabulated below to have a better perspective on how the four components can work individually thru their respective mechanisms of action, or together in synergistic combination thru their similarly shared active constituents toward a common goal in controlling the blood glucose level in a diabetic patient.