The present disclosure is directed to compositions comprising as an active ingredient, a lower dose of 4-({(1-cyclopropylisoquinolin-3-yl)[4-(trifluoromethoxy)benzyl] amino}sulfonyl)benzoic acid or a pharmaceutically acceptable salt thereof for treating or preventing vasomotor symptoms in a subject, and methods which comprises administering the said compound or the pharmaceutically acceptable salt thereof at a lower dose, respectively.本揭露係分別關於包含作為活性成分之較低劑量之4-({(1-環丙基異喹啉-3-基)[4-(三氟甲氧基)苄基]胺基}磺醯基)苯甲酸或其醫藥上可接受之鹽的用於治療或預防個體之血管舒縮症狀的組成物，以及包含以較低劑量給藥該化合物或其醫藥上可接受之鹽的方法。
