A method for delivering a therapeutic device to a target aortic valve site includes transseptally positioning a cable to run between a femoral artery, through the heart via an aortic valve, left ventricle, mitral valve, left atrium, and right atrium into the venous vasculature, the flexible member having a first end extending outside the body from a venous vessel superior to the heart and a second end external to the patient at the femoral artery. The aortic valve therapeutic device is attached to the cable outside the body and introduced into a femoral artery. A steerable sheath is advanced over the cable, into the venous vasculature and into the left ventricle of the heart. The aortic valve therapeutic device is pushed in a distal direction from the femoral artery while the cable is pulled from the venous vessel to advance the aortic valve therapeutic device to the target site. The sheath protects surrounding tissues from the cable during movement of the therapeutic device through the vasculature, and may be steered during final positioning to align the aortic valve therapeutic device at the target site.
