The purpose of the present invention is to provide a tacrolimus-containing pharmaceutical composition which is a creamy preparation for external application having a good sensation upon use and has high main ingredient stability (a high main ingredient residual ratio). The composition according to the present invention is an oil-in-water-type creamy composition characterized by comprising (A) tacrolimus, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, (B) diethyl sebacate and/or diisopropyl sebacate, (C) polyoxyethylene hydrogenated castor oil, (D) a hydrophilic polymer and (E) an anti-oxidative agent.
