Juan A. VERGEZ,Joaquina FAOUR,Ana C. PASTINI,Guido S. BIGATTI,Glenn A. MEYER,Ethel C. FELEDER,Marcelo A. RICCI,Marcelo A. COPPARI,Marcelo F. BEFUMO
申请号：
US13551755
公开号：
US20130115249A1
申请日:
2012.07.18
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The osmotic devices of the present invention contain a unitary core comprising a salt of amantadine and an osmotic salt, wherein the two salts have an ion in common. The release rate of the amantadine is a sigmoidal release. The osmotic device includes a semipermeable membrane having a controlled porosity that can be adapted as needed to cooperate with the osmotic salt in providing a predetermined drug release profile. The osmotic salt need not be coated and it is in admixture with the amantadine salt. The osmotic device further includes a drug-containing coat external to the semipermeable membrane. The osmotic device can include one or more additional drugs in the core and/or the drug-containing coat.
