CHROMOSOME HUMAIN ARTIFICIEL CONTENANT LE GENE A CHAINE LEGERE DE L'ANTICORPS HUMAIN .LAMBDA. ET ESPECE NON-HUMAINE CONTENANT LE CHROMOSOME ARTIFICIEL HUMAIN POUVANT SE TRANSMETTRE GENETIQUEMENT
The present invention relates to a human artificial chromosome which isgenetically transmissible to the next generation with high efficiency and themethod forusing the same. More specifically, the present invention relates to: a humanartificialchromosome in which an about 3.5 Mb to about 1 Mb region containing anantibody .lambda.light chain gene derived from human chromosome 22 is bound to a chromosomefragment which is transmissible to a progeny through a germ line of a non-humananimal, said chromosome fragment is derived from another human chromosome； anon-human animal carrying the human artificial chromosome and an offspringthereof； amethod for producing the non-human animal； a method for producing a humanantibodyusing the non-human animal or an offspring thereof； and a human antibodyproducingmouse carrying the human artificial chromosome.
