LYNCH, STEPHEN MATTHEW,NARAYANAN, ARJUN,STEINER, SANDRA
申请号：
CA2892368
公开号：
CA2892368A1
申请日:
2013.09.30
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein X, R1, R1´, R2, R2´, R3, R4, R4´ and R5 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease.
