Pyridine-pyridine (urea, hydrogen sulfide or guatedi) inhibitors； process for producing gene Nasaprocaine； synthesis of drugs containing this substance； and compounds used to treat pain, cancer, inflammation, neurodegenerative diseases or melamine-induced thyroid infections.
BLAKE, JAMES F.,HUANG, LILY,KERCHER, TIMOTHY,ALLEN, SHELLEY,ANDREWS, STEVEN W.,CONDROSKI, KEVIN R.,HAAS, JULIA,KOLAKOWSKI, GABRIELLE R.,SEO, JEONGBEOB,JIANG, YUTONG,HUANG LILY,KERCHER TIMOTHY,BLAKE JAMES F,ALLEN SHELLEY,ANDREWS STEVEN W,CONDROSKI KEVIN R,HAAS JULIA,JIANG YUTONG,KOLAKOWSKI GABRIELLE R,SEO JEONGBEOD
申请号：
CL2013003257
公开号：
CL2013003257A1
申请日:
2013.11.13
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C are as defined herein, and wherein the Y&mdash；B moiety and the NH&mdash；C(&boxH；X)&mdash；NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.COMPUESTOS DERIVADOS DE PIRROLIDINIL-(UREA, TIOUREA O GUANIDINA) INHIBIDORES DE QUIINASA TRKA； PROCESO PARA PREPARARLOS； COMPOSICION FARMACEUTICA QUE LOS COMPRENDE； Y SU USO PARA TRATAR DOLOR, CANCER, INFLAMACION, ENFERMEDAD NEURODEGENERATIVA O UNA INFECCION DE TRYPANOSOMA CRUZI.
