Charlotte ADMYRE,Arezou ZARGARI,Oliver VON STEIN,Petra VON STEIN
申请号：
US15711228
公开号：
US20180015117A1
申请日:
2017.09.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A method of treating chronic active ulcerative colitis in a subject that is refractory or responds insufficiently or is intolerant to anti-inflammatory therapy, comprises administering to a patient in need thereof an effective exposure of an oligonucleotide comprising the sequence 5′-GGAACAGTTCGTCCATGGC-3′ (SEQ ID NO.2), wherein at least one CG dinucleotide is unmethylated. The oligonucleotide is not administered with corticosteroids or glucocorticosteroids.
