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Processes for making cyclopropyl amide derivatives and intermediates associated therewith
专利权人:
ASTRAZENECA AB
发明人:
STRANNE ROBERT
申请号:
NZ60211011
公开号:
NZ602110A
申请日:
2011.02.17
申请国别(地区):
NZ
年份:
2014
代理人:
摘要:
Disclosed herein is a process for the preparation of compound (1S,2S)-2-(4-carbamoyl-phenyl)-cyclopropanecarboxylic acid according formula (Ia), comprising reacting a compound of formula IX with (1) a base and peroxide and then (2) an acidic solution. Also disclosed is a process for the preparation of compounds according formula (Ib) and (Ic) (4-{ (1S,2S)-2-[((R)-4-cyclobutyl-2-methylpiperazin-1-yl)carbonyl]-cyclopropyl} benzamide and 4-{ (1S,2S)-2-[(4-cyclobutylpiperazin-1-yl)carbonyl]-cyclopropyl} -benzamide respectively) starting from a compound of formula (Ia).
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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