GIBLIN, Gerard M P,MACPHERSON, David T,WITTY, David R,STANWAY, Steven J
申请号：
ES13725439
公开号：
ES2602308T3
申请日:
2013.05.22
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ** Formula ** wherein: ring A represents a phenyl ring, a 5- or 6-membered aromatic heterocyclic ring or an aromatic or non-aromatic bicyclic heterocyclic group of 5 to 12 members； n represents an integer selected from 0 to 4； each R 1 independently represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, -Z C 3-6 cycloalkyl, halogen, C 1-6 halogenoalkyl, C 1-6 alkoxy, C 1-6 halogenoalkoxy, -Z-phenyl, - Z-Het, -CN, -CONR6R7, - NR6R7, -Z-C1-3 alkyl, wherein said Het group represents a 5- to 6-membered aromatic heterocyclic ring or a 4 to 7-membered non-aromatic heterocyclic ring, wherein said phenyl or Het group of R1 may be optionally substituted with one or more (eg 1, 2 or 3) R8 groups and where n represents an integer greater than 1, said R1 groups representing no more than one -Z-phenyl group or -Z-Het； Z represents a link or linker selected from -O-, -CH2-, -CH2-O- or -O-CH2-； R6 and R7 independently represent hydrogen or C1-6 alkyl, or R6 and R7, together with the nitrogen atom to which they are attached, bind to form a non-aromatic heterocyclic ring containing 4-7 membered nitrogen； R 8 represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, halogen, C 1-6 halogenoalkyl, C 1-6 alkoxy, C 1-6 halogenoalkoxy, -CN or -NR6R7； m represents an integer selected from 0 to 2； each R2 independently represents C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halogen, C1-6 halogenoalkyl, C1-6 alkoxy, C1-6 halogenoalkoxy, -CN or -NR7R8； R3 represents hydrogen or C1-6 alkyl； R4 represents hydrogen or C1-6 alkyl； p represents an integer from 0 to 3； each R5 independently represents C1-3 alkyl or fluoro； Y represents -CH2- or - (CH2) 2-； q represents an integer selected from 0 to 2； and R9 represents C1-3 alkyl.Un compuesto de fórmula (I) o una sal farmacéuticamente aceptable del mismo: **Fórmula** donde: el anillo A representa un anillo de fenilo, un anillo heterocíclico aromático de 5 o 6 miembros o un grupo heteroc
