The invention provides antibodies that specifically bind to Plasminogen Activator Inhibitor type-1 (PAI-1). The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.本發明提供特異性結合第1型胞漿素原活化素抑制劑(PAI-1)的抗體。本發明還提供醫藥組成物，以及編碼抗PAI-1抗體的核酸，用於生成此類抗體的重組達現載體和宿主細胞，或其片段。還提供在體外或在體內使用抗體來調控PAI-1活性或檢測PAI-1的方法。本揭示進一步提供生成處於活性構象狀態的特異性結合PAI-1的抗體的方法。
