A method of treating a cellular stress-related disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an agent capable of enhancing processing of a pre-miRNA, thereby treating the cellular stress-related disease in the subject. Methods for treating motor neuron disease (MND) are also provided as well as pharmaceutical compositions.La présente invention concerne un procédé permettant de traiter une maladie du neurone moteur (MND) chez un patient en ayant besoin. Le procédé consiste à administrer au patient une quantité thérapeutiquement efficace d'un agent pouvant augmenter le traitement d'un pré-micro ARN, ce qui permet de traiter la MND chez le patient.